Low-Dose Aspirin and Sporadic Anovulation in the EAGeR Randomized Trial

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Low-Dose Aspirin and Sporadic Anovulation in the EAGeR Randomized Trial.

Context Among women with a single, recent pregnancy loss, daily preconception low-dose aspirin (LDA) increased the live birth rate with no effect on pregnancy loss. Ovulation is a potential mechanism underlying this effect. Objective We estimated the effect of LDA on the per-cycle risk of anovulation among eumenorrheic women. Design Multicenter, randomized, double-blind, placebo-controlled ...

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Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomized trial.

BACKGROUND Preconception-initiated low-dose aspirin might positively affect pregnancy outcomes, but this possibility has not been adequately assessed. Our aim was to investigate whether low-dose aspirin improved livebirth rates in women with one to two previous pregnancy losses. METHODS In this multicentre, block-randomised, double-blind, placebo-controlled trial, women aged 18-40 years who w...

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A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women.

BACKGROUND Randomized trials have shown that low-dose aspirin decreases the risk of a first myocardial infarction in men, with little effect on the risk of ischemic stroke. There are few similar data in women. METHODS We randomly assigned 39,876 initially healthy women 45 years of age or older to receive 100 mg of aspirin on alternate days or placebo and then monitored them for 10 years for a...

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Low-Dose Aspirin Does Not Lower Diabetes Incidence in Women A Randomized Trial of Low-Dose Aspirin in the Prevention of Clinical Type 2 Diabetes in Women

From the Center for Cardiovascular Disease Prevention (ADP, NRC, PMR, JEB), the Donald W. Reynolds Center for Cardiovascular Research (ADP, NRC, PMR), the Leducq Center for Molecular and Genetic Epidemiology of Cardiovascular Disorders (PMR), the Division of Cardiovascular Medicine (PMR) and Preventive Medicine (ADP, NRC, JEM, PMR, JEB), Brigham and Women’s Hospital and Harvard Medical School, ...

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Low-dose aspirin vs low-dose aspirin plus low-intensity warfarin in thromboprophylaxis: a prospective, multicentre, randomized, open, controlled trial in patients positive for antiphospholipid antibodies (ALIWAPAS).

OBJECTIVES The objectives of this study are to examine the efficacy and safety of low-dose aspirin (LDA) vs LDA plus low-intensity warfarin (LDA + W) in the primary thrombosis prevention of aPL-positive patients with SLE and/or obstetric morbidity and the role of clinical and serological markers in the development of thrombosis. METHODS In this 5-year prospective, randomized, open, controlled...

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ژورنال

عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism

سال: 2016

ISSN: 0021-972X,1945-7197

DOI: 10.1210/jc.2016-2095